1395374-36-3Relevant academic research and scientific papers
2-Bromo-6-[18F]fluoropyridine: Two-step fluorine-18 radiolabelling via transition metal-mediated chemistry
Betts, Helen M.,Robins, Edward G.
, p. 215 - 218 (2014)
Novel radiolabelling methods are important for the development of new tracers for positron emission tomography. Direct nucleophilic fluorination of aromatic rings with [18F]fluoride is limited to activated substrates, restricting the application of this approach. Inspired by transition metal-mediated transformations, a fluorine-18 synthon was prepared to supplement the radiolabelling methods available for molecules unsuitable for direct labelling. 2-Bromo-6-[18F]fluoropyridine (denoted [18F]1) was prepared in high yield, and palladium-mediated cross-coupling reactions were exemplified. High incorporation of fluoride and efficient cross-coupling reactions demonstrate that compound [18F]1 holds promise as a new synthon for construction of fluorine-18-labelled molecules via transition metal-mediated reactions.
RADIOFLUORINATION METHOD
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, (2012/09/21)
Provided by the present invention is a novel method for obtaining an 18F-labelled compound wherein said compound comprises an 18F-labelled pyridyl ring. The method of the invention is advantageous over the prior art methods as it provides these compounds in higher radiochemical yields than have been possible with previous methods. Also provided by the present invention is an 18F-labelled synthon useful in the method of the invention.
