1395435-10-5

Basic information

• Product Name: 3-(3-(2-methoxyphenyl)-4-oxo-2-thiazolidinyl)benzoic acid
• Synonyms: 3-(3-(2-methoxyphenyl)-4-oxo-2-thiazolidinyl)benzoic acid
• CAS NO: 1395435-10-5
• Molecular Weight: 329.376
• Mol File: 1395435-10-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-(3-(2-methoxyphenyl)-4-oxo-2-thiazolidinyl)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3-(2-methoxyphenyl)-4-oxo-2-thiazolidinyl)benzoic acid(1395435-10-5)
• EPA Substance Registry System: 3-(3-(2-methoxyphenyl)-4-oxo-2-thiazolidinyl)benzoic acid(1395435-10-5)

Safety Data

• Hazardous Substances Data: 1395435-10-5(Hazardous Substances Data)

Upstream product

• 52178-50-4 Methyl 3-formylbenzoate 
• 90-04-0 2-methoxy-phenylamine 
• 619-21-6 m-formylphenyl benzoic acid 
• 1395434-68-0 C₁₈H₁₇NO₄S 

Downstream Products

• 1395435-25-2 2-(3-(phenylaminocarbonyl)phenyl)-3-(2-methoxyphenyl)-4-thiazolidinone 
• 1395435-27-4 2-(3-(phenylethylaminocarbonyl)phenyl)-3-(2-methoxyphenyl)-4-thiazolidinone 
• 1395435-52-5 2-(3-N,N-diethylaminocarbonylphenyl)-3-(2-methoxyphenyl)-4-thiazolidinone 
• 1395435-19-4 2-(3-N,N-diallylaminocarbonylphenyl)-3-(2-methoxyphenyl)-4-thiazolidinone 
• 1612872-60-2 2-(3-(1-piperidinyl)carbonylphenyl)-3-(2-methoxyphenyl)-4-thiazolidinone 
• 1395435-23-0 2-(3-(benzylaminocarbonyl)phenyl)-3-(2-methoxyphenyl)-4-thiazolidinone 
• 1415251-35-2 2-(3-(phenylpropylaminocarbonyl)phenyl)-3-(2-methoxyphenyl)-4-thiazolidinone 
• 1415251-37-4 2-(3-(4-bromophenylethylaminocarbonyl)phenyl)-3-(2-methoxyphenyl)-4-thiazolidinone 
• 1415251-43-2 2-(3-(2-bromophenylethylaminocarbonyl)phenyl)-3-(2-methoxyphenyl)-4-thiazolidinone 
• 1415251-42-1 2-(3-(4-fluorophenylethylaminocarbonyl)phenyl)-3-(2-methoxyphenyl)-4-thiazolidinone 
• 1415251-39-6 2-(3-(4-chlorophenylethylaminocarbonyl)phenyl)-3-(2-methoxyphenyl)-4-thiazolidinone 
• 1415251-40-9 2-(3-(4-methoxyphenylethylaminocarbonyl)phenyl)-3-(2-methoxyphenyl)-4-thiazolidinone 
• 1415251-38-5 2-(3-(4-hydroxyphenylethylaminocarbonyl)phenyl)-3-(2-methoxyphenyl)-4-thiazolidinone 

Relevant articles and documents

A hybrid of thiazolidinone with the hydroxamate scaffold for developing novel histone deacetylase inhibitors with antitumor activities

A series of novel histone deacetylase (HDAC) inhibitors were designed, synthesized and evaluated based on the strategies of a hybrid of the classic pharmacophore of HDAC inhibitors with the thiazolidinone scaffold. Some of the compounds showed potent HDAC1 inhibition with nM IC50 values, more importantly, compound 12i displayed much better anti-metastatic effects than vorinostat (SAHA) against migration of the A549 cell line. Further mechanism exploration implied that compound 12i may inhibit tumor metastasis via modulating the epithelial-mesenchymal transition (EMT) and upregulating the acetylation of α-tubulin.