139547-89-0Relevant academic research and scientific papers
Synthesis and evaluation of 2-pyridinone derivatives as specific HIV-1 reverse transcriptase inhibitors. 3. Pyridyl and phenyl analogs of 3- aminopyridin-2(1H)-one
Wai,Williams,Bamberger,Fisher,Hoffman,Hudcosky,MacTough,Rooney,Saari,Thomas,Goldman,O'Brien,Emini,Nunberg,Quintero,Schleif,Anderson
, p. 249 - 255 (2007/10/02)
In an ongoing effort to develop novel nonnucleoside, specific human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) inhibitors, a series of 3-[(pyridylmethyl)amino]- and 3-[(phenylmethyl)amino]-2- pyridinone derivatives was synthesized an
Synergism of HIV reverse transcriptase inhibitors
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, (2008/06/13)
The combination of certain aminopyridones and anti-HIV nucleoside analogs has been found to synergistically inhibit HIV reverse transcriptase. This combination is useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as a combination of compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in further combination with other antivirals, anti-infectives, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
