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1395847-83-2

(S)-4-tert-butyl 1-((R)-2-(pent-4-enamido)-3-phenylpropyl)-2-allylsuccinate is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1395847-83-2 Structure

  • Basic information

    1. Product Name: (S)-4-tert-butyl 1-((R)-2-(pent-4-enamido)-3-phenylpropyl)-2-allylsuccinate
    2. Synonyms: (S)-4-tert-butyl 1-((R)-2-(pent-4-enamido)-3-phenylpropyl)-2-allylsuccinate
    3. CAS NO:1395847-83-2
    4. Molecular Formula:
    5. Molecular Weight: 429.557
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1395847-83-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (S)-4-tert-butyl 1-((R)-2-(pent-4-enamido)-3-phenylpropyl)-2-allylsuccinate(CAS DataBase Reference)
    10. NIST Chemistry Reference: (S)-4-tert-butyl 1-((R)-2-(pent-4-enamido)-3-phenylpropyl)-2-allylsuccinate(1395847-83-2)
    11. EPA Substance Registry System: (S)-4-tert-butyl 1-((R)-2-(pent-4-enamido)-3-phenylpropyl)-2-allylsuccinate(1395847-83-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1395847-83-2(Hazardous Substances Data)

1395847-83-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1395847-83-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,9,5,8,4 and 7 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1395847-83:
(9*1)+(8*3)+(7*9)+(6*5)+(5*8)+(4*4)+(3*7)+(2*8)+(1*3)=222
222 % 10 = 2
So 1395847-83-2 is a valid CAS Registry Number.

1395847-83-2Relevant articles and documents

SONIC HEDGEHOG MODULATORS

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Paragraph 0877; 0886; 1241, (2014/04/17)

Sonic Hedgehog modulators and methods of use thereof are provided for.

Macrocyclic hedgehog pathway inhibitors: Optimization of cellular activity and mode of action studies

Dockendorff, Chris,Nagiec, Marek M.,Weiwer, Michel,Buhrlage, Sara,Ting, Amal,Nag, Partha P.,Germain, Andrew,Kim, Han-Je,Youngsaye, Willmen,Scherer, Christina,Bennion, Melissa,Xue, Linlong,Stanton, Benjamin Z.,Lewis, Timothy A.,MacPherson, Lawrence,Palmer, Michelle,Foley, Michael A.,Perez, Jose R.,Schreiber, Stuart L.

supporting information, p. 808 - 813 (2013/01/15)

Macrocyclic Hedgehog (Hh) pathway inhibitors have been discovered with improved potency and maximal inhibition relative to the previously reported macrocycle robotnikinin. Analogues were prepared using a modular and efficient build-couple-pair (BCP) approach, with a ring-closing metathesis step to form the macrocyclic ring. Varying the position of the macrocycle nitrogen and oxygen atoms provided inhibitors with improved activity in cellular assays; the most potent analogue was 29 (BRD-6851), with an IC50 of 0.4 μM against C3H10T1/2 cells undergoing Hh-induced activation, as measured by Gli1 transcription and alkaline phosphatase induction. Studies with Patched knockout (Ptch-/-) cells and competition studies with the Smoothened (Smo) agonists SAG and purmorphamine demonstrate that in contrast to robotnikinin, select analogues are Smo antagonists.

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