1395875-91-8

Basic information

• Product Name: 2-(6-(cyclohexylmethylamino)-9-isopropyl-9H-purine-2-ylamino)-3-methylbutan-1-ol
• CAS NO: 1395875-91-8
• Molecular Weight: 374.53
• Mol File: 1395875-91-8.mol

Chemical Properties

• CAS DataBase Reference: 2-(6-(cyclohexylmethylamino)-9-isopropyl-9H-purine-2-ylamino)-3-methylbutan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(6-(cyclohexylmethylamino)-9-isopropyl-9H-purine-2-ylamino)-3-methylbutan-1-ol(1395875-91-8)
• EPA Substance Registry System: 2-(6-(cyclohexylmethylamino)-9-isopropyl-9H-purine-2-ylamino)-3-methylbutan-1-ol(1395875-91-8)

Safety Data

• Hazardous Substances Data: 1395875-91-8(Hazardous Substances Data)

Upstream product

• 1651-29-2 6-chloro-2-fluoro-7H-purine 
• 3218-02-8 cyclohexylmethylamine 
• 1395876-01-3 N-(cyclohexylmethyl)-2-fluoro-9H-purine-6-amine 

Relevant articles and documents

Design, synthesis and preliminary biological evaluation of purine-2,6-diamine derivatives as cyclin-dependent kinase (CDK) inhibitors

Novel purine-2,6-diamine derivatives were designed and synthesized as cyclin-dependent kinase (CDK) inhibitors. According to the preliminary biological evaluation, most of the compounds show good inhibitory activities in CDK1 enzyme assay and potent antiproliferative activities in some tumor cell lines. Especially, compound 11a (IC50=0.35 μmol/L for CDK1/cyclin B and IC50=0.023 μmol/L for CDK2/cyclin A) possessed better inhibitory effect compared with Roscovitine (IC50=2.54 (mol/L for CDK1/cyclin B and IC50=0.092 μmol/L for CDK2/cyclin A). Copyright