1395877-95-8Relevant academic research and scientific papers
Total synthesis of (+)-Sch 725680: Inhibitor of mammalian A-, B-, and Y-family DNA polymerases
Takeuchi, Toshifumi,Mizushina, Yoshiyuki,Takaichi, Satoshi,Inoue, Natsuki,Kuramochi, Kouji,Shimura, Satomi,Myobatake, Yusuke,Katayama, Yuri,Takemoto, Kenji,Endo, Shogo,Kamisuki, Shinji,Sugawara, Fumio
supporting information, p. 4303 - 4305 (2012/10/30)
The total synthesis of (+)-Sch 725680, a member of the hydrogenated azaphilone family, has been accomplished. The synthesis confirmed the absolute configuration and biological activities of the natural product. A key reaction to construct a hydrogenated azaphilone core skeleton is a Ti-mediated aldol reaction.
