1395895-63-2Relevant academic research and scientific papers
Cytotoxic lignans from fruits of Cleistanthus indochinensis: Synthesis of cleistantoxin derivatives
Trinh Thi Thanh, Van,Cuong Pham, Van,Doan Thi Mai, Huong,Litaudon, Marc,Gueritte, Francoise,Retailleau, Pascal,Nguyen, Van Hung,Chau, Van Minh
, p. 1578 - 1583 (2012)
Two new aryl-tetralin lignans, 1 and 2, were isolated from the fruits of Cleistanthus indochinensis by bioassay-guided purification. Their structures were determined by spectroscopic analysis including MS and 2D NMR. The absolute configurations of 1 and 2 were established from examination of their CD spectra. Compound 1 was cytotoxic against KB cells with an IC50 value of 0.022 μM, while compound 2 had weaker cytotoxicity, with an IC50 value of 1.4 μM. When tested against other cancer cell lines (MCF-7, MCF-7R, and HT29), 1 showed an IC50 of 0.014 against MCF-7R cells and an IC50 of 0.036 μM against MCF-7 cells. A series of amide derivatives of a new lactone, homoderivatives of 1, were prepared. Of these derivatives, only compound 3 had weak cytotoxicity against KB cells.
