1395920-22-5

Basic information

• Product Name: 3-(4-chloro-2-hydroxybenzyl)-5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazol-2(3H)-one
• Synonyms: 3-(4-chloro-2-hydroxybenzyl)-5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazol-2(3H)-one
• CAS NO: 1395920-22-5
• Molecular Weight: 370.715
• Mol File: 1395920-22-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(4-chloro-2-hydroxybenzyl)-5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazol-2(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-chloro-2-hydroxybenzyl)-5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazol-2(3H)-one(1395920-22-5)
• EPA Substance Registry System: 3-(4-chloro-2-hydroxybenzyl)-5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazol-2(3H)-one(1395920-22-5)

Safety Data

• Hazardous Substances Data: 1395920-22-5(Hazardous Substances Data)

Upstream product

• 339-59-3 4-(trifluoromethyl)benzoic acid hydrazide 
• 1261620-26-1 C₇H₆BrClO 
• 202823-22-1 5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-(3H)-one 

Relevant articles and documents

Propylene oxide assisted one-pot, tandem synthesis of substituted-1,3,4- oxadiazole-2(3H)-ones in water

It has been developed for the synthesis of substituted-1,3,4-oxadiazole- 2(3H)-one derivatives via a novel one-pot, tandem procedure assisted by propylene oxide. The 5-substitued-1,3,4-oxadiazole-2(3H)-ones and 3,5-disubstitued-1,3,4-oxadiazole-2(3H)-ones were, respectively, obtained from three-component reaction of acylhydrazines, carbon disulfide, and propylene oxide, and four-component reaction of acylhydarazines, carbon disulfide, propylene oxide, and organic halides. The reactions were carried out using water as solvent in the presence of potassium phosphate to afford the expected products in good to excellent yields.