1396178-71-4Relevant academic research and scientific papers
Design and synthesis of Pictet-Spengler condensation products that exhibit oncogenic-RAS synthetic lethality and induce non-apoptotic cell death
Skouta, Rachid,Hayano, Miki,Shimada, Kenichi,Stockwell, Brent R.
supporting information; experimental part, p. 5707 - 5713 (2012/10/07)
A series of Pictet-Spengler condensation derivatives (tetrahydro-β- carbolines) was designed, synthesized and evaluated for lethality against a panel of seven cancer cell lines. Seven compounds (2a, 13, 20, 21, 27, 29 and 34) showed lethality in at least five cell lines. Among these, compound 27 showed a unique selectivity towards oncogenic-RAS expressing BJ-TERT/LT/ST/RASV12 tumor cells, compared to non-transformed BJ-TERT cells. Further investigation revealed that 27 induces cell death without activation of caspases. This represents a useful new probe of non-apoptotic cell death and oncogenic-RAS synthetic lethality.
