1396259-14-5

Basic information

• Product Name: 7-fluoro-1-tosylindole
• Synonyms: 7-fluoro-1-tosylindole
• CAS NO: 1396259-14-5
• Molecular Weight: 289.33
• Mol File: 1396259-14-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 7-fluoro-1-tosylindole(CAS DataBase Reference)
• NIST Chemistry Reference: 7-fluoro-1-tosylindole(1396259-14-5)
• EPA Substance Registry System: 7-fluoro-1-tosylindole(1396259-14-5)

Safety Data

• Hazardous Substances Data: 1396259-14-5(Hazardous Substances Data)

Upstream product

• 387-44-0 7-fluoro-1H-indole 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 1396260-21-1 7-fluoro-1-(4-methoxybenzyl)-3-(β-D-xylopyranosyl)-1Hindole 
• 1396260-26-6 1-(4-cyclopropylbenzyl)-7-fluoro-3-(β-D-xylopyranosyl)-1Hindole 
• 1396260-57-3 C₄₂H₄₀FNO₅ 
• 1396259-57-6 C₃₄H₃₂FNO₄ 
• 1396259-44-1 C₄₁H₃₈FNO₆S 
• 887338-54-7 C₁₅H₁₁BrFNO₂S 

Relevant articles and documents

Practical and Scalable Synthesis of Borylated Heterocycles Using Bench-Stable Precursors of Metal-Free Lewis Pair Catalysts

A practical and scalable metal-free catalytic method for the borylation and borylative dearomatization of heteroarenes has been developed. This synthetic method uses inexpensive and conveniently synthesizable bench-stable precatalysts of the form 1-NHR2-2-BF3-C6H4, commercially and synthetically accessible heteroarenes as substrates, and pinacolborane as the borylation reagent. The preparation of several borylated heterocycles on 2 and 50 g scales was achieved under solvent-free conditions without the use of Schlenk techniques or a glovebox. A kilogram-scale borylation of one of the heteroarene substrates was also achieved using this cost-effective green methodology to exemplify the fact that our methodology can be conveniently implemented in fine chemical industries.

Synthesis and biological evaluation of novel C-indolylxylosides as sodium-dependent glucose co-transporter 2 inhibitors

Sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors are the current focus on the indication for the management of hyperglycemia in diabetes. Here, a novel series of C-linked indolylxyloside-based inhibitors of SGLT2 has been discovered. Structure-activity relationship studies revealed that substituents at the 7-position of the indole moiety and a p-cyclopropylphenyl group in the distal position were necessary for optimum inhibitory activity. The pharmacokinetic study demonstrates that the most potent compound 1i is metabolically stable with a low clearance in rats. In further efficacy study, 1i is found to significantly lower blood glucose levels of streptozotocin (STZ)-induced diabetic rats.