1396341-13-1

Basic information

• Product Name: (E)-3-(4-(methylamino)benzylidene)-5-bromoindolin-2-one
• Synonyms: (E)-3-(4-(methylamino)benzylidene)-5-bromoindolin-2-one
• CAS NO: 1396341-13-1
• Molecular Weight: 329.196
• Mol File: 1396341-13-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-3-(4-(methylamino)benzylidene)-5-bromoindolin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-(4-(methylamino)benzylidene)-5-bromoindolin-2-one(1396341-13-1)
• EPA Substance Registry System: (E)-3-(4-(methylamino)benzylidene)-5-bromoindolin-2-one(1396341-13-1)

Safety Data

• Hazardous Substances Data: 1396341-13-1(Hazardous Substances Data)

Upstream product

• 20870-78-4 5-bromo-2-indolin-2-one 
• 556-21-8 4-(methylamino)benzaldehyde 

Relevant articles and documents

Synthesis and biological evaluation of novel oxindole derivatives for imaging neurofibrillary tangles in Alzheimer's disease

This letter describes the synthesis and biological evaluation of a novel series of radioiodinated oxindole (OI) derivatives for detecting neurofibrillary tangles (NFTs) in the brains of patients with Alzheimer's disease (AD). In binding experiments in vitro, 2-oxindole (2-OI) and 3-oxindole (3-OI) derivatives showed affinity for tau aggregates. The 3-OI derivative 14 showed the highest affinity of these derivatives. In biodistribution experiments using normal mice, the OI derivatives displayed good uptake (2.4-2.5% ID/g at 2 min) and clearance from the brain with time (0.6-1.4% ID/g at 30 min). In fluorescence staining experiments using AD brain sections, 14 clearly stained NFTs. 3-OI may serve as a new molecular scaffold for developing novel NFT imaging agents.