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139655-04-2

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139655-04-2 Usage

General Description

1-(4-Nitro-phenyl)-2,3,4,9-tetrahydro-1H-beta-carboline, also known as 4-Nitro-tryptophan, is a chemical compound with the molecular formula C15H14N2O2. It is a beta-carboline derivative with a 4-nitro-phenyl group attached to the tetrahydro-beta-carboline core. 1-(4-NITRO-PHENYL)-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE has various pharmacological activities and has been studied for its potential role in central nervous system disorders, including neurodegenerative diseases and mood disorders. It has also been investigated for its potential as a therapeutic agent for cancer and inflammatory conditions. Research on the biological and pharmacological properties of 1-(4-Nitro-phenyl)-2,3,4,9-tetrahydro-1H-beta-carboline is ongoing to explore its potential applications in medicine and drug development.

Check Digit Verification of cas no

The CAS Registry Mumber 139655-04-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,9,6,5 and 5 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 139655-04:
(8*1)+(7*3)+(6*9)+(5*6)+(4*5)+(3*5)+(2*0)+(1*4)=152
152 % 10 = 2
So 139655-04-2 is a valid CAS Registry Number.

139655-04-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(4-nitrophenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole

1.2 Other means of identification

Product number -
Other names HMS620G04

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:139655-04-2 SDS

139655-04-2Relevant articles and documents

Microwave assisted Pictet-Spengler and Bischler-Napieralski reactions

Pal, Bikash,Jaisankar, Parasuraman,Giri, Venkatachalam S.

, p. 2339 - 2348 (2003)

Pictet-Spengler and Bischler-Napieralski reaction products have been prepared-using microwave irradiation on silicagel support under solvent free condition. Microwave assisted reactions have resulted in better yields of the desired products than prepared

Selective construction of alkaloid scaffolds by alcohol-based direct and mild aerobic oxidative Pictet-Spengler reactions

Han, Feng,Li, Huan,Liu, Haicheng,Liu, Jianping,Xu, Qing

supporting information, p. 7079 - 7085 (2020/10/02)

Employing TBN/TEMPO as the catalysts and oxygen as the oxidant, the biologically and pharmaceutically significant tetrahydro-β-carboline and β-carboline alkaloid scaffolds that used to be obtained by multi-step processes can now be selectively obtained in only one-stepviadirect aerobic oxidative Pictet-Spengler reactions of tryptamines with alcohols under mild conditions, with water generated as the byproduct. In this reaction, TBN/TEMPO was interestingly found to be able to facilitate the cyclization step of the whole reaction. This method tolerates a variety ofC- andN-substituted tryptamines, and both the more reactive benzylic and allylic alcohols and the less reactive aliphatic alcohols. This method can also be extended to dihydro-β-carboline synthesis and applied to the more available and more economical tryptophan for β-carboline synthesis, revealing its broad substrate scope and potential in synthetic applications.

Iodine-Catalyzed Metal-Free Oxidative Ring Opening of 1-Aryltetrahydro-β-carbolines: Facile Synthesis of C-2 Aroyl and Aryl Methanimino Indole Derivatives

Chauhan, Jyoti,Luthra, Tania,Sen, Subhabrata

supporting information, p. 4776 - 4786 (2018/09/06)

Indole derivatives bearing C-2 substituents have garnered a lot of attention due to their diverse biological activities. Various methods forthe synthesis of these compounds have been reported. Inspired by the hydrolysis of imines, an oxidative ring-opening reaction of 1-aryltetrahydro-β-carbolines with catalytic iodine in aqueous hydrogen peroxide, and also in the presence of appropriate amines, is described for the generation of 2-aroyl and arylmethanimine indole derivatives. The reaction proceeds under mild reaction conditions with ethanol as the solvent or under solvent-free conditions, respectively. This metal-free strategy facilitates the formation of the desired substituted C-2 indoles in moderate to excellent yields. The utility of this reaction is demonstrated by a facile multigram-scale synthesis of Luzindole, a selective melatonin receptor antagonist and an investigational drug against depression and disruption of the circadian rhythm.

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