139658-04-1 Usage
Description
(R)-6-METHOXY-2,5,7,8-TETRAMETHYLCHROMANE-2-CARBOXYLIC ACID, also known as rosmarinic acid, is a natural phenolic compound derived from various plants such as rosemary, lemon balm, and oregano. It exhibits antioxidant, anti-inflammatory, and antimicrobial properties, making it a promising candidate for use in pharmaceuticals, food, and cosmetic products. Rosmarinic acid has also demonstrated potential therapeutic applications in the treatment of cancer, neurodegenerative diseases, cardiovascular disorders, and skin conditions like atopic dermatitis.
Uses
Used in Pharmaceutical Industry:
(R)-6-METHOXY-2,5,7,8-TETRAMETHYLCHROMANE-2-CARBOXYLIC ACID is used as a therapeutic agent for its potential applications in the treatment of cancer, neurodegenerative diseases, and cardiovascular disorders. Its antioxidant, anti-inflammatory, and antimicrobial properties contribute to its effectiveness in managing these conditions.
Used in Food Industry:
(R)-6-METHOXY-2,5,7,8-TETRAMETHYLCHROMANE-2-CARBOXYLIC ACID is used as a natural preservative and flavor enhancer in food products due to its antioxidant and antimicrobial properties, which help extend shelf life and improve taste.
Used in Cosmetic Industry:
(R)-6-METHOXY-2,5,7,8-TETRAMETHYLCHROMANE-2-CARBOXYLIC ACID is used as an active ingredient in cosmetic products for its anti-inflammatory and antimicrobial properties, making it beneficial for managing skin conditions such as atopic dermatitis and promoting skin health.
Used in Antioxidant Applications:
(R)-6-METHOXY-2,5,7,8-TETRAMETHYLCHROMANE-2-CARBOXYLIC ACID is used as an antioxidant to protect cells from oxidative stress and damage, which may contribute to the prevention and treatment of various diseases and conditions.
Used in Anti-inflammatory Applications:
(R)-6-METHOXY-2,5,7,8-TETRAMETHYLCHROMANE-2-CARBOXYLIC ACID is used as an anti-inflammatory agent to reduce inflammation and alleviate symptoms associated with inflammatory conditions.
Used in Antimicrobial Applications:
(R)-6-METHOXY-2,5,7,8-TETRAMETHYLCHROMANE-2-CARBOXYLIC ACID is used as an antimicrobial agent to inhibit the growth of harmful microorganisms, contributing to the prevention and treatment of infections.
Check Digit Verification of cas no
The CAS Registry Mumber 139658-04-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,9,6,5 and 8 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 139658-04:
(8*1)+(7*3)+(6*9)+(5*6)+(4*5)+(3*8)+(2*0)+(1*4)=161
161 % 10 = 1
So 139658-04-1 is a valid CAS Registry Number.
139658-04-1Relevant articles and documents
A green multicomponent synthesis of tocopherol analogues with antiproliferative activities
Ingold, Mariana,Dapueto, Rosina,Victoria, Sabina,Galliusi, Germán,Batthyàny, Carlos,Bollati-Fogolín, Mariela,Tejedor, David,García-Tellado, Fernando,Padrón, José M.,Porcal, Williams,López, Gloria V.
, p. 1888 - 1902 (2017/11/15)
A one-pot efficient, practical and eco-friendly synthesis of tocopherol analogues has been developed using water or solvent free conditions via Passerini and Ugi multicomponent reactions. These reactions can be optimized using microwave irradiation or ultrasound as the energy source. Accordingly, a small library of 30 compounds was prepared for biological tests. The evaluation of the antiproliferative activity in the human solid tumor cell lines A549 (lung), HBL-100 (breast), HeLa (cervix), SW1573 (lung), T-47D (breast), and WiDr (colon) provided lead compounds with GI50 values between 1 and 5 μM. A structure–activity relationship is also discussed. One of the studied compounds comes up as a future candidate for the development of potent tocopherol-mimetic therapeutic agents for cancer.
Synthesis and biological evaluation of CX-659S and its related compounds for their inhibitory effects on the delayed-type hypersensitivity reaction
Tobe, Masanori,Isobe, Yoshiaki,Goto, Yuso,Obara, Fumihiro,Tsuchiya, Masami,Matsui, Junko,Hirota, Kosaku,Hayashi, Hideya
, p. 2037 - 2047 (2007/10/03)
In order to find novel nonsteroidal compounds possessing an inhibitory activity against delayed-type hypersensitivity (DTH) reactions, we conducted random screening using a picryl chloride (PC)-induced contact hypersensitivity reaction (CHR) in mice, and found compound 1 as a lead compound. Then we synthesized and evaluated an extensive series of 5-carboxamidouracil derivatives focused on both the uracil and the antioxidative moieties. Among them, we found that the hindered phenol moiety was necessary to exhibit the activities; especially, compounds 28a-28c having the partial structure of vitamin E were found to exert potent activities against the DTH reaction by both oral and topical administration. And compound 28c showed antioxidative activity against lipid peroxidation with an IC50 of 5.9μM. Compound 28c (CX-659S) was chosen as a candidate drug for the treatment of cutaneous disorders such as atopic dermatitis and allergic contact dermatitis. Copyright (C) 2000 Elsevier Science Ltd.
