139667-74-6

Basic information

• Product Name: CGP 52432
• Synonyms: 3-([[[(3,4-DICHLOROPHENYL)METHYL]AMINO]PROPYL] DIETHOXYMETHYL)PHOSPHINIC ACID;CGP 52432
• CAS NO: 139667-74-6
• Molecular Formula: C15H24Cl2NO4P
• Molecular Weight: 384.24
• EINECS: -0
• Product Categories: GABA/Glycine receptor;GABA
• Mol File: 139667-74-6.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 544.4°Cat760mmHg
• Flash Point: 283.1°C
• Appearance: white to beige/
• Density: 1.258g/cm³
• Vapor Pressure: 1.1E-12mmHg at 25°C
• Refractive Index: 1.524
• Storage Temp.: Desiccate at +4°C
• Solubility: H2O: soluble1mg/mL, clear (warmed)
• PKA: 2.26±0.50(Predicted)
• CAS DataBase Reference: CGP 52432(CAS DataBase Reference)
• NIST Chemistry Reference: CGP 52432(139667-74-6)
• EPA Substance Registry System: CGP 52432(139667-74-6)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 139667-74-6(Hazardous Substances Data)

Usage

Uses

CGP52432 has been used as a γ-aminobutyric acid B (GABAB) antagonist:to study its effects on the simulation of the onset of status epilepticus (SE) in micefor voltage-clamp recording in mice neuronsto study its effects on the GABAB receptor-mediated neurotransmission in guinea pig hippocampus

Biological Activity

Potent, selective GABA B receptor antagonist (IC 50 = 85 nM).

Biochem/physiol Actions

CGP52432 participates in inhibiting the glycine overflow in the hippocampus.

InChI:InChI=1/C15H24Cl2NO4P/c1-3-21-15(22-4-2)23(19,20)9-5-8-18-11-12-6-7-13(16)14(17)10-12/h6-7,10,15,18H,3-5,8-9,11H2,1-2H3,(H,19,20)