1396743-68-2

Upstream product

• 1396744-06-1 2-(1H-indole-3-carbonyl)-N-(4-(trifluoromethyl)phenyl)hydrazinecarbothioamide 
• 15317-58-5 1H-indole-3-carboxylic acid hydrazide 
• 1645-65-4 4-(trifluoromethyl)phenyl isothiocyanate 
• 776-41-0 indole-3-carboxylic acid ethyl ester 
• 771-50-6 1H-indole-3-carboxylic acid 

Relevant academic research and scientific papers

A series of 2-arylamino-5-(indolyl)-1,3,4-thiadiazoles as potent cytotoxic agents

A series of 2-arylamino-5-(indolyl)-1,3,4-thiadiazoles 6a-v were prepared and studied for their anticancer activity against selected human cancer cell lines. The reaction of indolylhydrazides 3a-h with a variety of aryl isothiocyanates 4 afforded the key intermediate thiosemicarbazides 5a-v, which upon treatment with acetyl chloride produced the 2-arylamino-5-(indolyl)-1,3,4- thiadiazoles 6a-v in good yields. Most of the synthesized compounds showed selective cytotoxicity towards human breast cancer cell line (MDA-MB-231). Of the synthesized 2-arylamino-5-(indolyl)-1,3,4-thiadiazoles, compound 6f is the most potent towards tested cancer cell lines (IC50 = 0.15-1.18 μM).