139727-45-0Relevant academic research and scientific papers
Structure-activity relationships of the antimalarial agent artemisinin. 2. Effect of heteroatom substitution at O-11: Synthesis and bioassay of N- alkyl-11-aza-9-desmethylartemisinins
Avery,Bonk,Chong,Mehrotra,Miller,Milhous,Goins,Venkatesan,Wyandt,Khan,Avery
, p. 5038 - 5044 (2007/10/03)
A novel class of artemisinin analogs, N-alkyl-11-aza-9- desmethylartemisinins 17-29, were synthesized via ozonolysis and acid- catalyzed cyclization of precursor amides 5-16. These amides were prepared through condensation of an activated ester of the kno
