1397395-18-4

Basic information

• Product Name: 1-phenyl-4-(4-fluoroanilinomethyl)-1H-1,2,3-triazole
• Synonyms: 1-phenyl-4-(4-fluoroanilinomethyl)-1H-1,2,3-triazole
• CAS NO: 1397395-18-4
• Molecular Weight: 268.293
• Mol File: 1397395-18-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-phenyl-4-(4-fluoroanilinomethyl)-1H-1,2,3-triazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-phenyl-4-(4-fluoroanilinomethyl)-1H-1,2,3-triazole(1397395-18-4)
• EPA Substance Registry System: 1-phenyl-4-(4-fluoroanilinomethyl)-1H-1,2,3-triazole(1397395-18-4)

Safety Data

• Hazardous Substances Data: 1397395-18-4(Hazardous Substances Data)

Upstream product

• 123685-60-9 4-fluoro-N-(prop-2-yn-1-yl)aniline 
• 622-37-7 Phenyl azide 

Relevant articles and documents

Recyclable clay supported Cu (II) catalyzed tandem one-pot synthesis of 1-aryl-1,2,3-triazoles

Montmorillonite KSF clay supported CuO nanoparticles efficiently catalyzes one-pot aromatic azidonation of aryl boronic acids followed by regioselective azide-alkyne 1,3-dipolar cycloaddition (CuAAC) reaction producing corresponding 1-aryl-1,2,3-triazole derivatives at room temperature in excellent yields without use of any additives. Investigations on mechanism of CuAAC revealed that sodium azide, which is used as azidonating reagent in one-pot protocol reduces Cu(II) to click-active Cu(I). The catalytic efficiency of another Cu(II) source CuSO4 in combination with NaN3 for this one-pot CuAAC protocol, further supported our mechanism. This is the first report for use of Cu(II)/NaN3 catalytic system for CuAAC protocol. The clay-Cu(II) catalyst being ligand-free, leaching-free, easy to synthesize from inexpensive commercially available precursors, recyclable, and environmentally friendly will be highly useful for economical synthesis of 1,4-disubstituted 1,2,3-triazoles.