139756-04-0

Basic information

• Product Name: 1H-Pyrazole-5-carboxaMide, 1-Methyl-4-[(2-propoxybenzoyl)aMino]-3-propyl-
• Synonyms: 1H-Pyrazole-5-carboxaMide, 1-Methyl-4-[(2-propoxybenzoyl)aMino]-3-propyl-;3-[[[5-(AMinocarbonyl)-1-Methyl-3-propyl-1H-pyrazol-4-yl]aMino]carbonyl]-4-propoxybenzene;2-methyl-4-[(2-propoxybenzoyl)amino]-5-propylpyrazole-3-carboxamide;1-Methyl-4-(2-propoxybenzamido)-3-propyl-1H-pyrazole-5-carboxamide
• CAS NO: 139756-04-0
• Molecular Formula: C₁₈H₂₄N₄O₃
• Molecular Weight: 344.40816
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 139756-04-0.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 1H-Pyrazole-5-carboxaMide, 1-Methyl-4-[(2-propoxybenzoyl)aMino]-3-propyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole-5-carboxaMide, 1-Methyl-4-[(2-propoxybenzoyl)aMino]-3-propyl-(139756-04-0)
• EPA Substance Registry System: 1H-Pyrazole-5-carboxaMide, 1-Methyl-4-[(2-propoxybenzoyl)aMino]-3-propyl-(139756-04-0)

Safety Data

• Hazardous Substances Data: 139756-04-0(Hazardous Substances Data)

Usage

Chemical Properties

Off-white Solid

Uses

Intermediate in the preparation of Sildenafil (S435000) analogues.

InChI:InChI=1S/C18H24N4O3/c1-4-8-13-15(16(17(19)23)22(3)21-13)20-18(24)12-9-6-7-10-14(12)25-11-5-2/h6-7,9-10H,4-5,8,11H2,1-3H3,(H2,19,23)(H,20,24)

Upstream product

• 54090-36-7 2-propoxybenzoyl chloride 
• 139756-02-8 4-amino-1-methyl-3-propyl-1H-pyrazole-5-carboxamide 
• 2100-31-4 2-propoxybenzoic acid 

Downstream Products

• 268203-93-6 5-[2-propyloxy-5-[2-(1-methyl-2-pyrrolidinyl)ethylaminosulfonyl]phenyl]-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidine-7-one 
• 139756-24-4 5-(5-chlorosulphonyl-2-n-propoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one 
• 374776-34-8 4-(5-chlorosulfonyl-2-n-propoxybenzamido)-1-methyl-3-n-propylpyrazole-5-carboxamide 
• 139756-23-3 5-(2-n-propoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one 
• 361340-57-0 1-methyl-5-(5-nitro-2-n-propoxyphenyl)-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one 
• 361340-58-1 5-(5-amino-2-n-propoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one 
• 374776-42-8 4-(5-(4-(3-ethoxycarbonylpropyl)piperidinylsulfonyl)-2-n-propoxybenzamido)-1-methyl-3-n-propylpyrazole-5-carboxamide 
• 374776-46-2 4-(5-(4-(2-ethoxycarbonylethyl)piperazinylsulfonyl)-2-n-propoxybenzamido)-1-methyl-3-n-propylpyrazole-5-carboxamide 
• 374776-40-6 4-(5-(4-(2-ethoxycarbonylethyl)piperidinylsulfonyl)-2-n-propoxybenzamido)-1-methyl-3-n-propylpyrazole-5-carboxamide 
• 374776-44-0 4-(5-(4-(ethoxycarbonylmethyl)piperazinylsulfonyl)-2-n-propoxybenzamido)-1-methyl-3-n-propylpyrazole-5-carboxamide 
• 374776-38-2 4-(5-(4-(ethoxycarbonylmethyl)piperidinylsulfonyl)-2-n-propoxybenzamido)-1-methyl-3-n-propylpyrazole-5-carboxamide 

Relevant articles and documents

Sedinafine derivatives of the microwave-assisted method for preparing

The invention discloses a microwave-assisted synthesis method of sildenafil derivatives, which mainly comprises the following steps: by using 2-alkoxybenzoic acid and 4-amino-1-methyl-3-n-propyl-1H-pyrazolyl-5-formamide as initial raw materials, carrying out amidation, cyclization, mononitration, nitro reduction, guanidylation and the like to obtain the sildenafil derivatives. The method greatly shortens the reaction time, enhances the reaction efficiency, has the advantages of high yield and high purity, is simple to operate and easy to control, and is beneficial to industrial production of sildenafil analogs.

Preparing pyrazolopyrimidinone derivatives for the treatment of impotence

The present invention relates to the method for preparing pyrazolopyrimidinone derivatives and their pharmaceutically acceptable salts having efficacy on the treatment of impotence, one of male sexual dysfunctions. The method according to the present invention comprises the steps of chlorosufonation the pyrazolamide, followed by amination with amine and intramolecular cyclization. The method provides the pyrazolopyrimidinone derivatives and their pharmaceutically acceptable salts with high yield and in an economic manner.

Pyrazolopyrimidinone antianginal agents

Compounds of the formula STR1 and pharmaceutically acceptable salts thereof are selective cGMP PDE inhibitors which are useful in the treatment of such diseases and adverse conditions as angina, hypertension, congestive heart failure, reduced blood vessel patency, peripheral vascular disease, stroke, bronchitis, chronic asthma, allergic asthma, allergic rhinitis, glaucoma, and diseases characterized by disorders of gut motility.