139764-31-1

Basic information

• Product Name: 2-Pyridineacetonitrile, a-methyl-a-phenyl-
• CAS NO: 139764-31-1
• Molecular Formula: C14H12N2
• Molecular Weight: 208.263
• Mol File: 139764-31-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-Pyridineacetonitrile, a-methyl-a-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyridineacetonitrile, a-methyl-a-phenyl-(139764-31-1)
• EPA Substance Registry System: 2-Pyridineacetonitrile, a-methyl-a-phenyl-(139764-31-1)

Safety Data

• Hazardous Substances Data: 139764-31-1(Hazardous Substances Data)

Upstream product

• 5005-36-7 phenyl-pyridin-2-yl-acetonitrile 
• 74-88-4 methyl iodide 
• 140-29-4 phenylacetonitrile 
• 109-04-6 2-bromo-pyridine 
• 372-48-5 2-fluoropyridine 
• 1823-91-2 1-phenylethyl cyanide 
• 109-09-1 2-chloropyridine 

Relevant articles and documents

Structure-activity relationship and cardiac safety of 2-aryl-2-(pyridin-2-yl)acetamides as a new class of broad-spectrum anticonvulsants derived from Disopyramide

A series of 2-aryl-2-(pyridin-2-yl)acetamides were synthesized and screened for their anticonvulsant activity in animal models of epilepsy. The compounds were broadly active in the ‘classical’ maximal electroshock seizure (MES) and subcutaneous Metrazol (scMET) tests as well as in the 6 Hz and kindling models of pharmacoresistant seizures. Furthermore, the compounds showed good therapeutic indices between anticonvulsant activity and motor impairment. Structure-activity relationship (SAR) trends clearly showed the highest activity resides in unsubstituted phenyl derivatives or compounds having ortho- and meta- substituents on the phenyl ring. The 2-aryl-2-(pyridin-2-yl)acetamides were derived by redesign of the cardiotoxic sodium channel blocker Disopyramide (DISO). Our results show that the compounds preserve the capability of the parent compound to inhibit voltage gated sodium currents in patch-clamp experiments; however, in contrast to DISO, a representative compound from the series 1 displays high levels of cardiac safety in a panel of in vitro and in vivo experiments.

EASY AND EFFICIENT SNAr REACTIONS ON HALOPYRIDINES IN SOLVENT FREE CONDITIONS

Solid-liquid phase transfer catalysis (PTC) without added solvent efficiently promotes SNAr reactions on halopyridines with a variety of anionic nucleophiles generated in situ.This metodology gives access to substituted pyridines in very simplified conditions depending on halide nature.Mechanistic investigations are proposed.