(3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol, also known as nat-20(S)-yne, is a byproduct of cholesterol oxidation and a potential agonist of the hedgehog signaling pathway. It is a form of 20(S)-hydroxy Cholesterol (20(S)-OHC) with a terminal alkyne group, which allows it to be used in linking reactions known as click chemistry. This molecule plays a significant role in regulating gene expression through the Gli transcription factors.
1397692-46-4
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Basic information
- Product Name: (3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol
- Synonyms: (3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol;SCMAJJQBADBBSM-CMJRPVKTSA-N;Nat-20(S)-yne
- CAS NO:1397692-46-4
- Molecular Formula: C25H38O2
- Molecular Weight: 370.56802
- EINECS: N/A
- Product Categories: Pharmaceuticals, Intermediates & Fine Chemicals, Steroids
- Mol File: 1397692-46-4.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: 510.0±25.0 °C(Predicted)
- Flash Point: N/A
- Appearance: /
- Density: 1.08±0.1 g/cm3(Predicted)
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- PKA: 14.68±0.29(Predicted)
- CAS DataBase Reference: (3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol(CAS DataBase Reference)
- NIST Chemistry Reference: (3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol(1397692-46-4)
- EPA Substance Registry System: (3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol(1397692-46-4)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 1397692-46-4(Hazardous Substances Data)
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1397692-46-4 Usage
Uses
Used in Pharmaceutical Industry:(3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol is used as a hedgehog signaling pathway agonist for its potential role in regulating gene expression. The activation of this pathway is selective for the nat-20(S)-OHC enantiomer and can be used to study the effects of hedgehog signaling on various cellular processes.
Used in Research and Development:
In the field of research and development, (3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol is used as a tool for click chemistry, allowing for the conjugation with magnetic beads and other bioactive molecules. This enables the capture or immobilization of bioactive molecules, which can be useful in various experimental setups and the development of new therapeutic strategies.
Used in Drug Delivery Systems:
Although not explicitly mentioned in the provided materials, the potential use of (3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol in drug delivery systems can be inferred due to its involvement in click chemistry. This molecule could be utilized to develop novel drug delivery systems that enhance the delivery, bioavailability, and therapeutic outcomes of hedgehog pathway modulators.
Check Digit Verification of cas no
The CAS Registry Mumber 1397692-46-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,9,7,6,9 and 2 respectively; the second part has 2 digits, 4 and 6 respectively.Calculate Digit Verification of CAS Registry Number 1397692-46:
(9*1)+(8*3)+(7*9)+(6*7)+(5*6)+(4*9)+(3*2)+(2*4)+(1*6)=224
224 % 10 = 4
So 1397692-46-4 is a valid CAS Registry Number.
1397692-46-4Upstream product
1397692-46-4Downstream Products
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(3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol
