1397693-34-3Relevant academic research and scientific papers
Parallel solid-phase synthesis of diaryltriazoles
Wrobel, Matthias,Aube, Jeffrey,Koenig, Burkhard
, p. 1027 - 1036 (2012)
A series of substituted diaryltriazoles was prepared by a solid-phase-synthesis protocol using a modified Wang resin. The copper(I)-or ruthenium(II)-catalyzed 1,3-cycloaddition on the polymer bead allowed a rapid synthesis of the target compounds in a parallel fashion with in many cases good to excellent yields. Substituted diaryltriazoles resemble a molecular structure similar to established terphenyl-alpha-helix peptide mimics and have therefore the potential to act as selective inhibitors for protein-protein interactions.
