1397708-32-5Relevant academic research and scientific papers
An efficient synthesis of bridged heterocycles from an Ir(I) bis-amination/ring-closing metathesis sequence
Brawn, Ryan A.,Guimaraes, Cristiano R. W.,McClure, Kim F.,Liras, Spiros
, p. 4802 - 4805,4 (2012/12/12)
The amination of bis-allylic imidates using an Iridium(I) catalyst leads to the efficient formation of 2,6-divinyl heterocycles. Careful screening of amines, solvents, and conditions has led to the discovery of a system that favors formation of the desired cis products with synthetically useful levels of diastereoselectivity, and these results are further explained by computer based transition state energy calculations. Exposure of the heterocycles to ring-closing metathesis catalysts leads to the desired bridged heterocyclic systems.
