1397710-19-8Relevant articles and documents
One-step synthesis of a fluorescein derivative and mechanistic studies
Cook, Michael P.,Ando, Shin,Koide, Kazunori
, p. 5284 - 5286 (2012)
We report a convenient method for the one-step synthesis of a fluorescein derivative under acidic conditions. Mechanistic studies indicate that the acid-promoted condensation of o-tolualdehyde and 4-chlororesorcinol to form the fluorescein derivative proceeds through a cyclization-oxidation pathway while an alternative oxidation-cyclization pathway remains possible.