139774-77-9Relevant academic research and scientific papers
Novel Nonopioid Non-Antiinflammatory Analgesics: 3-(Aminoalkyl)- and 3-oxazolopyridin-2(3H)-ones
Flouzat, Christine,Bresson, Yvette,Mattio, Anny,Bonnet, Jacqueline,Guillaumet, Gerald
, p. 497 - 503 (2007/10/02)
A series of 3-(aminoalkyl)- and 3-oxazolopyridin-2(3H)-ones were prepared from their respective oxazolopyridin-2(3H)-ones. Several members of this group were found to possess potent analgesic activity in the mouse during a p-phenylquinone writhing induced test. Among them, phenylpiperazine compounds with two-carbon length alkyl chains, 2a and 2b, appeared by high analgesic with little toxicity having neither an antiinflammatory effect nor opioid receptor affinity. The synthesis and structure-affinity relationships for this series are detailed.
Medicinal oxazolopyridine compounds
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, (2008/06/13)
Compounds of general formula (I): STR1 in which: R1 and R2 each represent a hydrogen atom or, with the nitrogen and oxygen which bear them, form an --O--CO--N link, W represents a halogen atom or a lower alkyl or alkoxy group optionally substituted with one or more halogen atoms, such as trifluoromethyl, and m being between 0 and 3, A is a linear or branched alkyl radical comprising from 1 to 6 carbon atoms, R3 and R4 are defined in the description have medicinal properties.
