1397836-49-5

Basic information

• Product Name: (Z)-2-ethoxy-3-((2'-(N'-hydroxycarbaMiMidoyl)biphenyl-4-yl)Methyl)-3H-benzo[d]iMidazole-4-carboxylic acid
• Synonyms: (Z)-2-ethoxy-3-((2'-(N'-hydroxycarbaMiMidoyl)biphenyl-4-yl)Methyl)-3H-benzo[d]iMidazole-4-carboxylic acid;(Z)-2-ethoxy-1-((2'-(N'-hydroxycarbamimidoyl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylic acid;Azilsartan Impurity 3
• CAS NO: 1397836-49-5
• Molecular Formula: C₂₄H₂₂N₄O₄
• Molecular Weight: 430.45588
• Mol File: 1397836-49-5.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: (Z)-2-ethoxy-3-((2'-(N'-hydroxycarbaMiMidoyl)biphenyl-4-yl)Methyl)-3H-benzo[d]iMidazole-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-2-ethoxy-3-((2'-(N'-hydroxycarbaMiMidoyl)biphenyl-4-yl)Methyl)-3H-benzo[d]iMidazole-4-carboxylic acid(1397836-49-5)
• EPA Substance Registry System: (Z)-2-ethoxy-3-((2'-(N'-hydroxycarbaMiMidoyl)biphenyl-4-yl)Methyl)-3H-benzo[d]iMidazole-4-carboxylic acid(1397836-49-5)

Safety Data

• Hazardous Substances Data: 1397836-49-5(Hazardous Substances Data)

Usage

Uses

Azilsartan Hyroxy Acid is an azilsartan (A926900) Impurity.

Upstream product

• 139481-44-0 methyl 1-[(2'-cyanobiphenyl-4-yl)methyl]-2-ethoxy-benzimidazole-7-carboxylate 
• 147403-65-4 methyl 2-ethoxy-1-((2′-(N′-hydroxycarbamimidoyl)-biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate 

Downstream Products

• 1449029-78-0 (5-methyl-2-oxo-1,3-dioxol-4-yl) methyl 2-ethoxy-1-[(2'-{N'-[(ethoxycarbonyl)oxy]carbamimidoyl}-biphenyl-4-yl)-methyl]-1H-benzimidazole-7-carboxylate 
• 1449029-80-4 (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-1-{[2'-(N'-{[(4-nitrophenoxy)carbonyl]oxy}carbamimidoyl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate 
• 863031-21-4 Azilsartan medoxomil 
• 1449029-77-9 (5-methyl-2-oxo-2H-1,3-dioxol-4yl)methyl 2-ethoxy-1-[(4-(2-[N-hydroxy-carbamimidoyl]phenyl)phenyl)-methyl]-1H-1,3-benzodiazole-7-carboxylate 
• 147403-03-0 azilsartan 

Relevant articles and documents

Method for greenly and efficiently synthesizing azilsartan in water phase

The invention relates to a method for greenly and efficiently synthesizing azilsartan in water phase, belonging to the field of medicines. The method comprises the following steps: by taking water asa solvent and 1-[(2'-hydroxyamidino)[1,1-biphenyl]-4-yl]-2-ethoxyl-1H-benzimidazole-7-methyl formate and carbonylation reagent as starting raw materials, performing one-step reaction under base interaction to synthesize azilsartan. Esterification, cyclization and hydrolysis reactions are simplified into one step, so that the reaction time is extremely shortened, the reaction yield is increased, and the purity of the product is high. By taking water as a reactive solvent, the defects of the prior art that an organic solvent is high in toxicity, production is insafe and the like can be overcome,and a simple and efficient green synthesis method is provided for synthesis of azilsartan.

arab League Qi Shatan ester or its salt synthetic method and intermediates thereof, and method for synthesizing intermediate (by machine translation)

The invention relates to the field of medicines and in particular relates to a synthesis method for azilsartan medoxomil or salt thereof, an intermediate of the azilsartan medoxomil or the salt thereof and a synthesis method for the intermediate. According to the novel method for the azilsartan medoxomil or the salt thereof, the problems of low synthesized azilsartan medoxomil yield and large number of byproducts are solved. Furthermore, the invention further provides a synthesis intermediate of the azilsartan medoxomil or the salt thereof and two preparation methods. In a synthesis process, an alcohol fragment of the azilsartan medoxomil is introduced at first, so that a part of the azilsartan medoxomil is formed, and a cyclization structure fragment is synthesized; therefore, the problem that the yield is reduced because of side reaction caused by active hydrogen in a carbonyldimidazole structure of an azilsartan acid structure is solved in a reaction process; the reaction yield is greatly improved, so that a finished product is easier to purify; the synthesis method is particularly suitable for industrial production.

PROCESS FOR THE PREPARATION OF AZILSARTAN MEDOXOMIL OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF

The present invention relates to a process for the preparation of azilsartan medoxomil or pharmaceutically acceptable salts thereof.