1397877-44-9

Basic information

• Product Name: 5-(4-chlorophenyl)-N-phenyl-2-(4-nitrobenzylidene)-7-methyl-3-oxo-2,3-dihydro-5H-(1,3)-oxazolo-(3,2-a)-pyrimidine-6-carboxamide
• CAS NO: 1397877-44-9
• Molecular Weight: 514.925
• Mol File: 1397877-44-9.mol

Chemical Properties

• CAS DataBase Reference: 5-(4-chlorophenyl)-N-phenyl-2-(4-nitrobenzylidene)-7-methyl-3-oxo-2,3-dihydro-5H-(1,3)-oxazolo-(3,2-a)-pyrimidine-6-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-chlorophenyl)-N-phenyl-2-(4-nitrobenzylidene)-7-methyl-3-oxo-2,3-dihydro-5H-(1,3)-oxazolo-(3,2-a)-pyrimidine-6-carboxamide(1397877-44-9)
• EPA Substance Registry System: 5-(4-chlorophenyl)-N-phenyl-2-(4-nitrobenzylidene)-7-methyl-3-oxo-2,3-dihydro-5H-(1,3)-oxazolo-(3,2-a)-pyrimidine-6-carboxamide(1397877-44-9)

Safety Data

• Hazardous Substances Data: 1397877-44-9(Hazardous Substances Data)

Upstream product

• 419546-39-7 6-(4-chlorophenyl)-4-methyl-2-oxo-N-phenyl-1,2,3,6-tetrahydropyrimidine-5-carboxamide 
• 555-16-8 4-nitrobenzaldehdye 
• 79-11-8 chloroacetic acid 

Relevant articles and documents

In vitro anti-inflammatory potential and QSAR analysis of oxazolo/thiazolo pyrimidine derivatives

Twenty-six different benzylidene oxazolo/thiazolo (3,2-a)-pyrimidine-6- carboxamide derivatives were synthesized and evaluated for their anti-inflammatory potential by protein denaturation method. The structures of title compounds were characterized by IR and NMR spectral data. The SAR studies reveal that compounds containing electron withdrawing polar group at para position of 5-phenyl ring and electron withdrawing non-polar group at para position of 2-benzylidene moiety of thiazolo pyrimidine nucleus have better anti-inflammatory potential. The 2D-QSAR studies were performed on VLife MDS software which reveals that anti-inflammatory potential of benzylidene-3-oxo-5H- oxazolo/thiazolo (3,2-a)-pyrimidine-6-carboxamides is dependent on estate contribution, alignment independent, individual and path count descriptors.