1397922-61-0

Basic information

• Product Name: Pyrotinib Maleate
• Synonyms: Pyrotinib Maleate
• CAS NO: 1397922-61-0
• Molecular Weight: 699.163
• Mol File: 1397922-61-0.mol

Chemical Properties

• CAS DataBase Reference: Pyrotinib Maleate(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrotinib Maleate(1397922-61-0)
• EPA Substance Registry System: Pyrotinib Maleate(1397922-61-0)

Safety Data

• Hazardous Substances Data: 1397922-61-0(Hazardous Substances Data)

Usage

Uses

Used in Oncology:
Pyrotinib Maleate is used as a targeted therapy agent for the treatment of HER2-positive advanced or metastatic breast cancer. It works by inhibiting the tyrosine kinase activity of the HER family of receptors, which are overexpressed in certain types of cancer cells, thereby blocking tumor cell growth and proliferation.
Used in Pharmaceutical Industry:
Pyrotinib Maleate is used as a pharmaceutical compound for the development of cancer treatments, specifically for HER2-positive breast cancer. Its ability to target and inhibit the HER family of receptors makes it a valuable asset in the field of oncology, offering a more precise and effective approach to cancer treatment.
Used in Clinical Research:
Pyrotinib Maleate is used as a subject of clinical studies to evaluate its efficacy and safety in improving progression-free survival and overall survival in patients with advanced HER2-positive breast cancer. These studies provide valuable insights into the potential benefits and risks associated with the use of Pyrotinib Maleate as a targeted therapy for breast cancer patients.

Upstream product

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Relevant articles and documents

CRYSTALLINE FORM I OF TYROSINE KINASE INHIBITOR DIMALEATE AND PREPARATION METHODS THEREOF

Provided are crystalline Form I of (R,E)-N-(4-(3-chloro-4-(pyridin-2-yl -methoxy)-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl)-3-(1-methylpyrr olidin-2-yl) propenamide dimaleate (called SHR1258 dimaleate for short), preparation methods thereof and pharmac

CRYSTALLINE FORM I OF TYROSINE KINASE INHIBITOR DIMALEATE AND PREPARATION METHODS THEREOF

Provided are crystalline Form I of (R,E)-N-(4-(3-chloro-4-(pyridin-2-yl -methoxy)-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl)-3-(1-methylpyrr olidin-2-yl) propenamide dimaleate (called SHR1258 dimaleate for short), preparation methods thereof, and pharma

PHARMACEUTICALLY ACCEPTABLE SALT OF (E)-N-[4-[[3-CHLORO-4-(2-PYRIDYLMETHOXY)PHENYL]AMINO]-3-CYANO-7-ETHOXY-6-QUINOLYL]-3-[(2R)-1-METHYLPYRROLIDIN-2-YL]PROP-2-ENAMIDE, PREPARATION METHOD THEREFOR, AND MEDICAL USE THEREOF

Provided as represented by formula (I) is a pharmaceutically acceptable salt of (E)-N-[4-[[3-chloro-4-(2-pyridylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolyl] -3-[(2R)-1-methylpyrrolidin-2-yl]prop-2-enamide, a preparation method therefor, and a use thereof as a therapeutic agent and especially as a protein kinase inhibitor.

PHARMACEUTICALLY ACCEPTABLE SALT OF (E)-N-[4-[[3-CHLORO-4-(2-PYRIDYLMETHOXY)PHENYL]AMINO]-3-CYANO-7-ETHOXY-6-QUINOLYL]-3-[(2R)-1-METHYLPYRROLIDIN-2-YL]PROP-2-ENAMIDE, PREPARATION METHOD THEREOF, AND MEDICAL USE THEREOF

Provided as represented by formula (I) is a pharmaceutically acceptable salt of (E)-N-[4-[[3-chloro-4-(2-pyridylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolyl]-3-[(2R)-1-methylpyrrolidin-2-yl]prop-2-enamide, a preparation method thereof, and a use thereof as a therapeutic agent, and especially as a protein kinase inhibitor.