1397956-77-2Relevant academic research and scientific papers
Novel hydroxyethylaminomethylchromenones derivatives which inhibit the interleukin-5 activity
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Paragraph 0178; 0282-0291, (2016/10/09)
The present invention relates to a novel hydroxyethylaminomethylchromenone derivative, a manufacturing method thereof, or a pharmaceutical composition including the hydroxyethylaminomethylchromenone derivative for preventing or treating allergic diseases. Since the hydroxyethylaminomethylchromenone derivative is low-molecular, non-peptide-based material, the derivative has no non-specific reaction for proteins unlike existing treating agents known for allergic diseases. In addition, the hydroxyethylaminomethylchromenone derivative of the present invention is an amine-form compound, and thereby, remarkably increasing water solubility compared to the existing hydroxyethylaminomethylchromenone derivatives manufactured, as well as having higher effects of inhibiting interleukin-5 activities due to difference in chemical structures, such that the compound of the present invention can be effectively used as an inhibitor for allergic diseases. Furthermore, since the existing hydroxyethylaminomethylchromenone derivatives have a chiral center, it produces inconvenience as it requires to check whether the an isomer exists or not. However, the present invention solves the inconvenience so as to have an advantage of being capable of easily manufacturing a compound. [Reference numerals] (AA,CC) Compound 3d; (BB,DD) Compound 4i
Novel interleukin-5 inhibitors based on hydroxyethylaminomethyl-4H-chromen- 4-one scaffold
Joo, Cheonik,Venkateswararao, Eeda,Lee, Ki-Cheul,Sharma, Vinay K.,Kyung, Min-Sik,Kim, Youngsoo,Jung, Sang-Hun
, p. 5757 - 5762 (2012/10/30)
Hydroxyethylaminomethyl-4H-chromenones were previously discovered as fairly strong IL-5 inhibitor. For determination of detail structure activity relationship, N-substituted hydroxyethylaminomethylchromenones 4a-n were prepared and evaluated for their IL-
