1398076-36-2

Basic information

• Product Name: 5-trifluoromethyl-3-phenyl-1H-1-(2-naphthoxyacetyl)pyrazole
• Synonyms: 5-trifluoromethyl-3-phenyl-1H-1-(2-naphthoxyacetyl)pyrazole
• CAS NO: 1398076-36-2
• Molecular Weight: 396.369
• Mol File: 1398076-36-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-trifluoromethyl-3-phenyl-1H-1-(2-naphthoxyacetyl)pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-trifluoromethyl-3-phenyl-1H-1-(2-naphthoxyacetyl)pyrazole(1398076-36-2)
• EPA Substance Registry System: 5-trifluoromethyl-3-phenyl-1H-1-(2-naphthoxyacetyl)pyrazole(1398076-36-2)

Safety Data

• Hazardous Substances Data: 1398076-36-2(Hazardous Substances Data)

Upstream product

• 135-19-3 β-naphthol 
• 36304-47-9 1-(2-naphthyloxyacetyl)hydrazine 
• 6036-14-2 ethyl (naphthalen-2-yloxy)acetate 
• 1398075-84-7 5-trifluoromethyl-5-hydroxy-4,5-dihydro-3-phenyl-1H-1-(2-naphthoxyacetyl)pyrazole 

Relevant articles and documents

Regioselective sy nthesis and antimicrobial evaluation of new 1-aryloxyacetyl-, 1-thiophenoxyacetyl- and 1-phenylaminoacetylsubstituted 3-alkyl(aryl/heteroaryl)-5-trifluoromethyl-5-hydroxy-4,5-dihydro-1H-pyrazoles

This paper describes an efficient approach for the regioselective synthesis of new series of twenty 1-aryloxy(thio)acetyl and 1-(phenylamino)acetyl- substituted 5-trifluoromethyl-5-hydroxy-4,5-dihydro-1H-pyrazoles (3) in 34-96% yields from the cyclocondensation reaction of 4-alkoxy-4-alkyl-(aryl/heteroaryl) -1,1,1-trifluoroalk-3-en-2-ones with different substituted acetohydrazides. Dehydration reactions of 3, carried out in the presence of thionyl chloride, furnished two examples of aromatic 5-trifluoromethyl-1H-pyrazole derivatives, in 78-82% yields. From antimicrobial tests the fungi C. albicans proved to be particularly susceptible to the action of 1-(phenylamino)acetyl-substituted 3-alkyl-2-pyrazoline derivatives; however the first results are still weak when compared to standard drugs. ARKAT-USA, Inc.