1398180-01-2Relevant academic research and scientific papers
Copper-Mediated Deuterotrifluoromethylation of α?Diazo Esters
Hu, Mingyou,Xie, Qiqiang,Li, Xinjin,Ni, Chuanfa,Hu, Jinbo
supporting information, p. 469 - 472 (2016/05/24)
A copper-mediated deuterotrifluoromethylation of α?diazo esters under the promotion of deuterium oxide (D2O) has been developed for the synthesis of deuterium-labeled trifluoromethyl compounds. This deuterotrifluoromethylation reaction is of broad scope and can afford the deuterated products with higher than 99% isotopic purity. Moreover, the results of this investigation also provide some experimental evidences to support our previously proposed trifluoromethylation mechanism.
Copper-mediated trifluoromethylation of α-diazo esters with TMSCF3: The important role of water as a promoter
Hu, Mingyou,Ni, Chuanfa,Hu, Jinbo
supporting information, p. 15257 - 15260 (2012/10/29)
Copper-mediated trifluoromethylation of α-diazo esters with TMSCF3 reagent has been developed as a new method to prepare α-trifluoromethyl esters. This trifluoromethylation reaction represents the first example of fluoroalkylation of a non-fluorinated carbene precursor. Water plays an important role in promoting the reaction by activating the "CuCF3" species prepared from CuI/TMSCF3/CsF (1.0:1.1:1.1). The scope of this trifluoromethylation reaction is broad, and its efficiency is demonstrated in the synthesis of a variety of aryl-, benzyl-, and alkyl-substituted 3,3,3-trifluoropropanoates.
