1398398-70-3Relevant academic research and scientific papers
Pd-catalyzed direct C-H bond functionalization of spirocyclic σ1 ligands: Generation of a pharmacophore model and analysis of the reverse binding mode by Docking into a 3D homology model of the σ1 receptor
Meyer, Christina,Schepmann, Dirk,Wuensch, Bernhard,Yanagisawa, Shuichi,Yamaguchi, Junichiro,Itami, Kenichiro,Dal Col, Valentina,Laurini, Erik,Pricl, Sabrina
, p. 8047 - 8065,19 (2020/09/15)
To explore the hydrophobic binding region of the σ1 receptor protein, regioisomeric spirocyclic thiophenes 9-11 were developed as versatile building blocks. Regioselective α- and β-arylation using the catalyst systems PdCl2/bipy/Ags
Late-stage C-H bond arylation of spirocyclic σ1 ligands for analysis of complementary σ1 receptor surface
Meyer, Christina,Schepmann, Dirk,Yanagisawa, Shuichi,Yamaguchi, Junichiro,Itami, Kenichiro,Wuensch, Bernhard
, p. 5972 - 5979 (2013/01/15)
Direct C-H bond arylation in the α- and β-positions of spirocyclic thiophenes containing various functional groups (amine, ether, acetal, lactone) was accomplished. Selective phenylation in the α-position of the thiophene ring was achieved by using the ca
