1398507-07-7

Upstream product

• 5637-42-3 1-(4-cyanophenyl)guanidine 
• 105-56-6 ethyl 2-cyanoacetate 

Downstream Products

• 269055-15-4 etravirine 
• 1398507-08-8 4-((4-amino-6-chloropyrimidin-2-yl)amino)benzonitrile 
• 1404118-66-6 N-[6-chloro-2-(4-cyanophenylamino)pyrimidin-4-yl]benzamide 
• 1404118-67-7 N-[5-bromo-6-chloro-2-(4-cyanophenylamino)-pyrimidin-4-yl]-benzamide 
• 1404118-68-8 N-[5-bromo-6-(4-cyano-2,6-dimethylphenoxy)-2-(4-cyano-phenylamino)pyrimidin-4-yl]-benzamide 

Relevant academic research and scientific papers

PROCESS FOR THE PRODUCTION OF ETRAVIRINE

A novel process for the preparation of Etravirine comprises the condensing of ethyl cyanoacetate with N-cyanophenylguanidine to obtain an —OH compound of formula (II), which is further converted to a leaving group of formula (III). The compound of formula (III) is optionally protected and brominated to yield compound of formula (IV). The condensation of formula (IV) with 3,5-dimethyl-4-hydroxybenzonitrile yields a compound of formula (VI), and an optional deprotection of the compound of formula (VI) results in Etravirine.

NOVEL PROCESS FOR THE PREPARATION OF ETRAVIRINE

The present invention relates to a novel process for the preparation of Etravirine, comprises; condensing ethyl cyanoacetate with N-cyanophenylguanidine to obtain -OH compound of formula (II), which is further converted to a leaving group of formula (III). Compound of formula (III) is optionally protected and brominated to yield compound of formula (IV). Condensation of formula (IV) with 3,5-dimethyl-4-hydroxybenzonitrile gives formula (VI), and an optional deprotection of formula (VI) results into Etravirine. The present invention further relates to process for purifying Etravirine. The present invention also provides novel intermediates of Etravirine.