1398508-17-2Relevant academic research and scientific papers
Discovery of the investigational drug TAK-441, a pyrrolo[3,2-c]pyridine derivative, as a highly potent and orally active hedgehog signaling inhibitor: Modification of the core skeleton for improved solubility
Ohashi, Tomohiro,Oguro, Yuya,Tanaka, Toshio,Shiokawa, Zenyu,Tanaka, Yuta,Shibata, Sachio,Sato, Yoshihiko,Yamakawa, Hiroko,Hattori, Harumi,Yamamoto, Yukiko,Kondo, Shigeru,Miyamoto, Maki,Nishihara, Mitsuhiro,Ishimura, Yoshimasa,Tojo, Hideaki,Baba, Atsuo,Sasaki, Satoshi
, p. 5507 - 5517 (2012/10/30)
We recently reported the discovery of the novel pyrrolo[3,2-c]quinoline-4- one derivative 1 as a potent inhibitor of Hedgehog (Hh) pathway signaling. However, the PK evaluation of 1 at high dosage (100 mg/kg) revealed the C max value 3.63 μg/mL
