1398509-75-5

Upstream product

• 1765-93-1 4-fluoroboronic acid 
• 1417519-79-9 3-bromo-2-(4-fluorophenyl)pyridine 
• 536-74-3 phenylacetylene 
• 111079-39-1 2-chloro-3-(2-phenylethynyl)pyridine 

Downstream Products

• 1398509-85-7 (Z)-5-benzylidene-7-fluoro-5H-indeno[1,2-b]pyridine 
• 1398509-95-9 (E)-5-benzylidene-7-fluoro-5H-indeno[1,2-b]pyridine 

Relevant academic research and scientific papers

Cycloisomerization – a straightforward way to benzo[h]quinolines and benzo[c]acridines

[Figure not available: see fulltext.] Cycloisomerization of 3-alkynyl-2-arylpyridines and quinolines offers a straightforward approach to benzo[h]quinolines and benzo[c]-acridines. Substituent at the triple bond governs a choice between transition metal or Br?nsted acid catalysis. A direct electrophilic activation by trifluoromethanesulfonic acid induces an almost quantitative cyclization of the o-aryl(phenylethynyl) fragment. PtCl2 efficiently catalyzes cyclization of 2-aryl-3-ethynylhetarenes.

Rh(III)-catalyzed C-H bond activation along with "rollover" for the synthesis of 4-azafluorenes

An intramolecular reaction of 3-alkynyl and 3-alkenyl-2-arylpyridines selectively gave 4-azafluorene compounds in the presence of a catalytic amount of [Cp*RhCl2]2 and Cu(OAc)2. Pyridine-directed C-H bond activation along