1398566-79-4Relevant academic research and scientific papers
Michael addition of N-unprotected 2-oxindoles to nitrostyrene catalyzed by bifunctional tertiary amines: Crucial role of dispersion interactions
Reiter, Christoph,Lopez-Molina, Sonia,Schmid, Bernhard,Neiss, Christian,Goerling, Andreas,Tsogoeva, Svetlana B.
, p. 1324 - 1332 (2014/05/20)
Bifunctional thiourea- or sulfonamide-derived tertiary amines catalyze the enantioselective nitro-Michael addition of N-unprotected 3-substituted 2-oxindoles to nitrostyrene in up to 99 % yields, 94:6 er, and 87:13 dr. Overcoming the necessity to introduc
Asymmetric synthesis of 3-spirocyclopropyl-2-oxindoles via intramolecular trapping of chiral aza-ortho-xylylene
Dou, Xiaowei,Yao, Weijun,Zhou, Bo,Lu, Yixin
supporting information, p. 9224 - 9226 (2013/09/24)
Chiral aza-ortho-xylylene intermediates were efficiently generated from 3-chloro-3-substituted oxindole precursors. The first intramolecular trapping of chiral aza-ortho-xylylene intermediates led to a highly asymmetric synthesis of 3-spirocyclopropyl-2-oxindoles.
