1398608-88-2Relevant academic research and scientific papers
Solid-phase synthesis of a library of C-terminal agmatine dipeptides using a backbone amide linker (BAL) strategy
Ang, Melgious Jin Yan,Lim, Huichang Annie,Chia, Cheng San Brian
, p. 5511 - 5514 (2012)
In this Letter, we report a novel solid-phase strategy using a backbone amide linker (BAL) attached to a polystyrene support for the synthesis of C-terminal agmatine dipeptides. Our method eliminates the need to purify intermediates by column chromatography and enables us to build rapidly an 18-member library of C-terminal agmatine dipeptides which are subsequently screened for inhibitory activity against a viral enzyme. 2012 Elsevier Ltd. All rights reserved.
