1398627-07-0Relevant articles and documents
1,1-Dioxo-5,6-dihydro-[4,1,2]oxathiazines, a novel class of 11?-HSD1 inhibitors for the treatment of diabetes
B?hme, Thomas,Engel, Christian K.,Farjot, Géraldine,Güssregen, Stefan,Haack, Torsten,Tschank, Georg,Ritter, Kurt
, p. 4685 - 4691 (2013/08/15)
Racemic cis-1,1-dioxo-5,6-dihydro-[4,1,2]oxathiazine derivative 4a was isolated as an impurity in a sample of a hit from a HTS campaign on 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). After separation by chiral chromatography the 4a-S, 8a-R enantio