1398705-09-3

Basic information

• Product Name: C₁₆H₂₃NO₃
• Synonyms: C₁₆H₂₃NO₃
• CAS NO: 1398705-09-3
• Molecular Weight: 277.364
• Mol File: 1398705-09-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₆H₂₃NO₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₆H₂₃NO₃(1398705-09-3)
• EPA Substance Registry System: C₁₆H₂₃NO₃(1398705-09-3)

Safety Data

• Hazardous Substances Data: 1398705-09-3(Hazardous Substances Data)

Upstream product

• 142253-56-3 3-hydroxymethyl-azetidine-1-carboxylic acid tert-butyl ester 
• 142253-55-2 1-(t-butyloxycarbonyl)-azetidine-3-carboxylic acid 
• 177947-96-5 tert-butyl 3-formylazetidine-1-carboxylate 
• 1589-82-8 phenylmagnesium bromide 

Downstream Products

• 1398705-13-9 1-(azetidin-3-yl)-2-(phenyl)ethanol hydrochloride 

Relevant articles and documents

Exploration of novel 3-substituted azetidine derivatives as triple reuptake inhibitors

Novel azetidines based on the 3-aryl-3-oxypropylamine scaffold were designed, synthesized, and evaluated as TRIs. Reduction of 1 followed by Swern oxidation and then Grignard reaction gave 3. The alkylation of 3 provided the corresponding azetidine derivatives 6, of which the two most promising, 6bd and 6be, were selected from 86 prepared analogues based on their biological profiles. Compound 6be showed activity in vivo in FST at 10 mg/kg IV or 20-40 mg/kg PO.