Calnexin is a type I integral membrane protein that resides in the endoplasmic reticulum (ER) and plays a key role in the folding and quality control of newly synthesized glycoproteins. It is a calcium-binding chaperone protein that assists in the folding of glycoproteins by interacting with high-mannose-type oligosaccharides on the nascent polypeptide chains. Calnexin acts as a molecular chaperone by preventing the aggregation of misfolded proteins and promoting their correct folding. It also interacts with other ER-resident proteins, such as calreticulin and ERp57, to form a protein complex involved in glycoprotein quality control. Additionally, calnexin has been implicated in various cellular processes, including cell adhesion, immune response, and calcium signaling. Dysregulation of calnexin function has been associated with diseases such as autoimmune disorders and cancer.
139873-08-8
Post Buying Request-
-
Basic information
- Product Name: calnexin
- Synonyms: calnexin
- CAS NO:139873-08-8
- Molecular Formula:
- Molecular Weight: 0
- EINECS: N/A
- Product Categories: N/A
- Mol File: 139873-08-8.mol
-
Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: calnexin(CAS DataBase Reference)
- NIST Chemistry Reference: calnexin(139873-08-8)
- EPA Substance Registry System: calnexin(139873-08-8)
-
Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 139873-08-8(Hazardous Substances Data)
139873-08-8 Suppliers
Recommended suppliersmore
139873-08-8 Usage
Uses
Used in Biomedical Research:Calnexin is used as a molecular chaperone for the folding and quality control of newly synthesized glycoproteins. It is essential in preventing the aggregation of misfolded proteins and promoting their correct folding, which is crucial for understanding protein folding mechanisms and related diseases.
Used in Cell Biology:
Calnexin is used as a key component in the endoplasmic reticulum's protein folding and quality control system. It is involved in the interaction with other ER-resident proteins, such as calreticulin and ERp57, to form a protein complex that is vital for glycoprotein quality control.
Used in Disease Studies:
Calnexin is used as a potential therapeutic target for autoimmune disorders and cancer. Its dysregulation has been associated with these diseases, making it a subject of interest for researchers seeking to understand the underlying mechanisms and develop treatments.
Used in Drug Development:
Calnexin is used as a target for the development of drugs that could potentially modulate its function, which may have therapeutic applications in treating diseases associated with its dysregulation, such as autoimmune disorders and cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 139873-08-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,9,8,7 and 3 respectively; the second part has 2 digits, 0 and 8 respectively.Calculate Digit Verification of CAS Registry Number 139873-08:
(8*1)+(7*3)+(6*9)+(5*8)+(4*7)+(3*3)+(2*0)+(1*8)=168
168 % 10 = 8
So 139873-08-8 is a valid CAS Registry Number.
139873-08-8Upstream product
139873-08-8Downstream Products
Post a RFQ
1
What can I do for you?
Get Best Price
Get Best Price for 139873-08-8
calnexin
