1398744-13-2Relevant academic research and scientific papers
Scalable Synthesis of Diazeniumdiolates: Application to the Preparation of MK-8150
Zhong, Yong-Li,Weisel, Mark,Humphrey, Guy R.,Muzzio, Daniel J.,Zhang, Li,Huffman, Mark A.,Zhong, Wendy,Maloney, Kevin M.,Campos, Kevin R.
, p. 4210 - 4214 (2019)
Synthetic diazeniumdiolate (DAZD)-based nitric oxide is utilized to modulate the nitric oxide (NO) concentration in cellular environments and to control physiological processes, yet chemists are still struggling to find efficient and scalable methodologies that will enable them to access sufficient quantities of the high-energy diazeniumdiolate intermediates for biological studies. Now, a general, scalable, safer, and high-yielding new methodology adaptable to the large-scale synthesis of DAZDs has been developed.
PRIMARY AMINE DIAZENIUMDIOLATE HETEROCYCLIC DERIVATIVES
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, (2012/09/22)
A compound having the structure useful for treating hypertension, Pulmonary Arterial Hypertension (PAH), congestive heart failure, conditions resulting from excessive water retention, cardiovascular disease, diabetes, oxidative stress, endothelial dysfunction, cirrhosis, pre-eclampsia, osteoporosis or nephropathy.
