139887-90-4Relevant articles and documents
Synthesis of Deoxydinucleoside Phosphates Containing 4-Thio Substituted Pyrimidine Nucleobases
Clivio, Pascale,Fourrey, Jean-Louis,Gasche, Jeanette,Favre, Alain
, p. 2383 - 2388 (2007/10/02)
The preparations, by the hydrogenphosphonate approach in solution, of the five pyrimidine deoxydinucleoside monophosphates 14a, 14b, 16a, 16b and 17 containing a 4-thiosubstituted pyrimidine nucleobase at either their 3'- or 5'-end are described.These syntheses were conveniently accomplished using 4-thionucleoside derivatives having their sulfur function protected by S-pivaloyloxymethylation.The behaviour of unprotected 4-thionucleoside derivatives was also investigated and they were shown to give comparable overall yields.