D-THREO-1-PHENYL-2-HEXADECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL, also known as D-threo-PPMP, is a glucosylceramide (GlyCer) synthetase inhibitor. It is the active enantiomer and enzymatic inhibitory component of the racemic DL-threo-PPMP. D-threo-PPMP has demonstrated the ability to induce a 70% reduction in cell growth in MDCK kidney epithelial cells in vitro at 20 μM and significantly inhibit DNA synthesis at 3 μM.
139889-65-9
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Basic information
- Product Name: D-THREO-1-PHENYL-2-HEXADECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL
- Synonyms: D-THREO-1-PHENYL-2-HEXADECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL;D-THREO-PPMP
- CAS NO:139889-65-9
- Molecular Formula: C29H51ClN2O3
- Molecular Weight: 511.17984
- EINECS: N/A
- Product Categories: N/A
- Mol File: 139889-65-9.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: D-THREO-1-PHENYL-2-HEXADECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL(CAS DataBase Reference)
- NIST Chemistry Reference: D-THREO-1-PHENYL-2-HEXADECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL(139889-65-9)
- EPA Substance Registry System: D-THREO-1-PHENYL-2-HEXADECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL(139889-65-9)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 139889-65-9(Hazardous Substances Data)
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139889-65-9 Usage
Uses
Used in Pharmaceutical Industry:D-THREO-1-PHENYL-2-HEXADECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL is used as an enzymatic inhibitor for the inhibition of glucosylceramide synthetase. This application is significant due to its potential role in the development and progression of various diseases, including cancer and neurodegenerative disorders.
Used in Research Applications:
D-threo-PPMP is used as a research tool for studying the role of glucosylceramide synthetase in cellular processes and its potential as a therapeutic target. The compound's ability to inhibit DNA synthesis and reduce cell growth makes it a valuable asset in understanding the underlying mechanisms of disease and the development of novel treatment strategies.
Used in Drug Development:
D-THREO-1-PHENYL-2-HEXADECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL is used as a lead compound in the development of new drugs targeting glucosylceramide synthetase. Its potent inhibitory effects on cell growth and DNA synthesis make it a promising candidate for further optimization and development into a therapeutic agent for various diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 139889-65-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,9,8,8 and 9 respectively; the second part has 2 digits, 6 and 5 respectively.Calculate Digit Verification of CAS Registry Number 139889-65:
(8*1)+(7*3)+(6*9)+(5*8)+(4*8)+(3*9)+(2*6)+(1*5)=199
199 % 10 = 9
So 139889-65-9 is a valid CAS Registry Number.
139889-65-9Upstream product
139889-65-9Downstream Products
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D-THREO-1-PHENYL-2-HEXADECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL
