139892-29-8Relevant academic research and scientific papers
SYNTHESIS OF (+)-8a,9-SECOARTEMISININ AND RELATED ANALOGS
Avery, Mitchell A.,Chong, Wesley K. M.,Detre, George
, p. 1799 - 1802 (2007/10/02)
An efficient synthesis of (+)-8a,9-secoartemisinin 2, a ring-D cleaved, tricyclic analog of (+)-artemisinin 1, has been accomplished.Dioxetane 7, produced upon ozonolysis of vinyl-silane 5 in methanol, was intercepted with acid to provide the stable bicylic peroxy-aldehyde 9, which was readily converted to the title compound(s).
