13990-04-0 Usage
General Description
L-3,5-Dichlorophenylalanine is a chemical compound that belongs to the phenylalanine family, which is a type of amino acid. It is characterized by the presence of two chlorine atoms in the 3 and 5 positions of the phenyl ring. L-3,5-Dichlorophenylalanine is often used in the field of medicinal chemistry and pharmacology for its potential therapeutic properties. It has been studied for its potential as an enzyme inhibitor and as a precursor for the synthesis of other pharmaceuticals. L-3,5-Dichlorophenylalanine has also been investigated for its role in the treatment of various diseases and disorders, particularly in the context of neurotransmitter function and neurotransmitter-related disorders. Overall, this compound is a subject of ongoing research and has the potential for various applications in the fields of medicine and drug development.
Check Digit Verification of cas no
The CAS Registry Mumber 13990-04-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,9,9 and 0 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 13990-04:
(7*1)+(6*3)+(5*9)+(4*9)+(3*0)+(2*0)+(1*4)=110
110 % 10 = 0
So 13990-04-0 is a valid CAS Registry Number.
13990-04-0Relevant articles and documents
Telescopic one-pot condensation-hydroamination strategy for the synthesis of optically pure L-phenylalanines from benzaldehydes
Parmeggiani, Fabio,Ahmed, Syed T.,Weise, Nicholas J.,Turner, Nicholas J.
, p. 7256 - 7262 (2016/10/26)
A chemo-enzymatic telescopic approach was designed for the synthesis of L-arylalanines in high yield and optical purity, starting from commercially available and inexpensive substituted benzaldehydes. The method exploits a chemical Knoevenagel–Doebner condensation (optimised to give complete conversions in a short reaction time, employing microwave irradiation) and a biocatalytic phenylalanine ammonia lyase mediated hydroamination (for the stereoselective addition of ammonia). The two reactions can be run sequentially in one pot, bringing together the advantages of chemical and biological catalysis. The preparative applicability was demonstrated with the synthesis of five L-dihalophenylalanines (71–84% yield, 98–99% ee) of relevance as molecular probes, for medicinal chemistry and for the synthesis of pharmaceutical ingredients.
