1399085-97-2Relevant academic research and scientific papers
Metal free TBHP-promoted intramolecular carbonylation of arenes: Via radical cross-dehydrogenative coupling: Synthesis of indenoquinolinones, 4-azafluorenones and fluorenones
Mishra, Kalpana,Pandey, Ashok Kumar,Singh, Jay Bahadur,Singh, Radhey M.
, p. 6328 - 6336 (2016/07/11)
A metal-free, TBHP-promoted economical route is developed via the sp2 C-H bond functionalization strategy for the synthesis of indenoquinolinones, 4-azafluorenones and fluorenones. Reactions provided excellent yield of the products under mild conditions. We have successfully synthesized 11H-indeno[1,2-b]quinolin-11-one, an antibacterial agent, in excellent yields.
An organocatalytic cascade approach toward polysubstituted quinolines and chiral 1,4-dihydroquinolines-unanticipated effect of N-protecting groups
Zhang, Xinshuai,Song, Xixi,Li, Hao,Zhang, Shilei,Chen, Xiaobei,Yu, Xinhong,Wang, Wei
, p. 7282 - 7286 (2012/09/08)
A matter of protection: The outcome of a divergent organocatalytic aza-Michael/aldol cascade process toward quinolines and 1,4-dihydroquinolines depends on the choice of the N-protecting group (see scheme; TEA=triethylamine, TMS=trimethylsilyl). Use of an electron-donating sulfonyl group results in an unanticipated aza-Michael/aldol/aromatization cascade to give polysubstituted quinolines (right). In contrast, chiral 1,4-dihydroquinolines are obtained with an electron-withdrawing sulfonyl group (left). Copyright
