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1-(2-chloroethyl)-3-(3-chlorophenyl)-1-nitrosourea, commonly known as CCNU, is a chemotherapeutic agent characterized by its alkylating properties. It is designed to target and damage the DNA of cancer cells, thereby inducing cell death. CCNU is orally administered and demonstrates rapid absorption, with peak levels achieved within 1-2 hours post-ingestion. 1-(2-chloroethyl)-3-(3-chlorophenyl)-1-nitrosourea undergoes metabolism in the liver and is subsequently excreted through the urine. Despite its efficacy against various cancer types, CCNU is associated with side effects such as nausea, vomiting, bone marrow suppression, and liver toxicity, necessitating close patient monitoring and regular blood tests to evaluate liver and kidney function.

13991-75-8

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13991-75-8 Usage

Uses

Used in Oncology:
CCNU is utilized as a chemotherapeutic agent for the treatment of various cancer types, including brain tumors and lymphoma. It functions by alkylating and damaging the DNA of cancer cells, which in turn leads to cell death and hinders tumor growth. The rapid absorption of CCNU after oral administration allows for effective targeting of cancer cells with minimal impact on healthy cells.
Used in Drug Resistance Management:
CCNU is also employed in managing drug resistance in cancer treatment. Its alkylating action can enhance the chemo-sensitivity of cancer cells, making them more susceptible to the effects of conventional chemotherapeutic drugs. This property is particularly beneficial in cases where tumors have developed resistance to standard treatments, thereby improving the overall efficacy of cancer management strategies.
Used in Pharmaceutical Research and Development:
As a chemotherapeutic agent, CCNU serves as a valuable compound in the ongoing research and development of novel cancer treatments. Its mechanism of action and pharmacokinetic profile provide insights into the design of new drugs and drug delivery systems aimed at improving the efficacy and safety of cancer therapies.

Check Digit Verification of cas no

The CAS Registry Mumber 13991-75-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,9,9 and 1 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 13991-75:
(7*1)+(6*3)+(5*9)+(4*9)+(3*1)+(2*7)+(1*5)=128
128 % 10 = 8
So 13991-75-8 is a valid CAS Registry Number.

13991-75-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(2-chloroethyl)-3-(3-chlorophenyl)-1-nitrosourea

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:13991-75-8 SDS

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