13991-75-8

Basic information

• Product Name: 1-(2-chloroethyl)-3-(3-chlorophenyl)-1-nitrosourea
• CAS NO: 13991-75-8
• Molecular Formula: C₉H₉Cl₂N₃O₂
• Molecular Weight: 262.0927
• Mol File: 13991-75-8.mol
• Article Data: 1

Chemical Properties

• Density: 1.43g/cm³
• Refractive Index: 1.6
• CAS DataBase Reference: 1-(2-chloroethyl)-3-(3-chlorophenyl)-1-nitrosourea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-chloroethyl)-3-(3-chlorophenyl)-1-nitrosourea(13991-75-8)
• EPA Substance Registry System: 1-(2-chloroethyl)-3-(3-chlorophenyl)-1-nitrosourea(13991-75-8)

Safety Data

• Hazardous Substances Data: 13991-75-8(Hazardous Substances Data)

Usage

General Description

1-(2-chloroethyl)-3-(3-chlorophenyl)-1-nitrosourea, also known as CCNU, is a chemotherapeutic agent used in the treatment of various types of cancer, including brain tumors and lymphoma. It is an alkylating agent that works by damaging the DNA of cancer cells, leading to their death. CCNU is administered orally and is well-absorbed by the body, with peak levels being reached within 1-2 hours after ingestion. It is metabolized in the liver and excreted in the urine. Common side effects of CCNU include nausea, vomiting, bone marrow suppression, and liver toxicity. It is important for patients receiving CCNU to be closely monitored for potential adverse effects and to receive regular blood tests to assess their liver and kidney function.

Upstream product

• 2909-38-8 m-chlorophenyl isocyanate 
• 13908-34-4 1-(2-chloroethyl)-3-(m-chlorophenyl)-urea 

Relevant articles and documents

The synthesis of potential anticancer agents. XXXVI. N-nitrosoureas. II. Haloalkyl derivatives.

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