1399134-29-2Relevant academic research and scientific papers
Synthesis and cytotoxic activity of non-naturally substituted 4-oxycoumarin derivatives
Serra, Silvia,Delogu, Giovanna,Casu, Laura,Vazquez-Rodriguez, Saleta,Santana, Lourdes,Uriarte, Eugenio,Chicca, Andrea,Gertsch, Juerg
, p. 5791 - 5794,4 (2012)
Coumarins are a large family of natural and synthetic compounds exerting different pharmacological effects, including cytotoxic, anti-inflammatory or antimicrobial. In the present communication we report the synthesis of a series of 12 diversely substituted 4-oxycoumarin derivatives including methoxy substituted 4-hydroxycoumarins, methyl, methoxy or unsubstituted 3-aryl-4-hydroxycoumarins and 4-benzyloxycoumarins and their anti-proliferative effects on breast adenocarcinoma cells (MCF-7), human promyelocytic leukemia cells (HL-60), human histiocytic lymphoma cells (U937) and mouse neuroblastoma cells (Neuro2a). The most potent bioactive molecule was the 4-hydroxy-5,7- dimethoxycoumarin (compound 1) which showed similar potency (IC50 0.2-2 μM) in all cancer cell lines tested. This non-natural product reveals a simple bioactive scaffold which may be exploited in further studies.
