139915-43-8 Usage
Description
2-[(7-Nitro-2,1,3-benzoxadiazol-4-yl)thio]ethanamine is a chemical compound characterized by its unique structure, which features a 7-nitro-2,1,3-benzoxadiazol-4-yl group attached to an ethanamine molecule through a sulfur atom. 2-[(7-Nitro-2,1,3-benzoxadiazol-4-yl)thio]ethanaMine is known for its distinct chemical properties and potential applications in various fields.
Uses
Used in Fluorescent Dye Preparation:
2-[(7-Nitro-2,1,3-benzoxadiazol-4-yl)thio]ethanamine is used as a key component in the preparation of fluorescent N/S acyl derivatives. These derivatives are valuable in various applications, such as bioimaging, sensing, and diagnostics, due to their ability to emit fluorescence upon exposure to specific wavelengths of light.
Used in Chemical Research and Development:
In the field of chemical research and development, 2-[(7-Nitro-2,1,3-benzoxadiazol-4-yl)thio]ethanamine serves as a versatile building block for the synthesis of novel compounds with potential applications in various industries, including pharmaceuticals, materials science, and environmental science.
Used in Analytical Chemistry:
2-[(7-Nitro-2,1,3-benzoxadiazol-4-yl)thio]ethanamine can be employed as a reagent or a label in analytical chemistry for the detection and quantification of specific molecules or ions. Its fluorescent properties make it an attractive candidate for the development of sensitive and selective assays.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-[(7-Nitro-2,1,3-benzoxadiazol-4-yl)thio]ethanamine may be utilized as an intermediate in the synthesis of new drugs or drug candidates, particularly those with potential applications in the treatment of various diseases and conditions.
Used in Material Science:
The unique properties of 2-[(7-Nitro-2,1,3-benzoxadiazol-4-yl)thio]ethanamine make it a promising candidate for the development of new materials with specific optical, electronic, or mechanical properties. These materials could find applications in various industries, such as electronics, optics, and aerospace.
Check Digit Verification of cas no
The CAS Registry Mumber 139915-43-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,9,9,1 and 5 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 139915-43:
(8*1)+(7*3)+(6*9)+(5*9)+(4*1)+(3*5)+(2*4)+(1*3)=158
158 % 10 = 8
So 139915-43-8 is a valid CAS Registry Number.
139915-43-8Relevant articles and documents
The fight against the influenza A virus H1N1: Synthesis, molecular modeling, and biological evaluation of benzofurazan derivatives as viral RNA polymerase inhibitors
Pagano, Mafalda,Castagnolo, Daniele,Bernardini, Martina,Fallacara, Anna Lucia,Laurenzana, Ilaria,Deodato, Davide,Kessler, Ulrich,Pilger, Beatrice,Stergiou, Lilli,Strunze, Stephan,Tintori, Cristina,Botta, Maurizio
, p. 129 - 150 (2014/01/17)
The influenza RNA polymerase complex, which consists of the three subunits PA, PB1, and PB2, is a promising target for the development of new antiviral drugs. A large library of benzofurazan compounds was synthesized and assayed against influenza virus A/WSN/33 (H1N1). Most of the new derivatives were found to act by inhibiting the viral RNA polymerase complex through disruption of the complex formed between subunits PA and PB1. Docking studies were also performed to elucidate the binding mode of benzofurazans within the PB1 binding site in PA and to identify amino acids involved in their mechanism of action. The predicted binding pose is fully consistent with the biological data and lays the foundation for the rational development of more effective PA-PB1 inhibitors. In the fight against influenza virus A/WSN/33 (H1N1), the PA-PB1 protein-protein interaction is emerging as a new drug target. To identify small molecules able to inhibit the viral RNA polymerase complex, the benzofurazan scaffold was explored by synthesizing a large library of derivatives. Some compounds showed high anti-H1N1 activity and emerged as effective inhibitors of the PA-PB1 interaction, with IC50 values in the micromolar range. Copyright
