139925-41-0

Upstream product

• 74-96-4 ethyl bromide 
• 63328-00-7 (2S)-O-(p-toluenesulfonyl)-N-(p-toluenesulfonyl)phenylalaninol 
• 140145-73-9 R-(+)-(3-Phenyl-2-tosylamido)propyl-tosylat 
• 1202798-72-8 N-((1R,2S)-1-chloro-1-phenylpentan-2-yl)-4-methylbenzenesulfonamide 

Downstream Products

• 139925-46-5 S-(-)-Prolintan 
• 87982-81-8 S-(+)-1-phenyl-2-aminopentane 
• 139925-42-1 R-(+)-Prolintan 
• 87982-79-4 R-(-)-1-phenyl-2-aminopentane 

Relevant academic research and scientific papers

BF3·OEt2-Mediated highly regioselective S N2-type ring-opening of N-activated aziridines and N-activated azetidines by tetraalkylammonium halides

(Chemical Equation Presented) A highly regioselective Lewis acid-mediated SN2-type ring-opening of N-sulfonylaziridines and azetidines with tetraalkylammonium halides in CH2Cl2 solution to afford 1,2- and 1,3-haloamines in excellent yields is described. An easy diastereoselective route toward substituted chiral N-tosylaziridines has been developed. The mechanism of ring-opening via SN2 pathway has been confirmed by the formation of chiral haloamines with excellent er and dr. Chloroamines obtained from 2,3-disubstituted aziridines were converted to the chiral N-tosylamines via radical dehalogenation. 2009 American Chemical Society.

Synthesis of possible metabolites and the enantiomers of prolintane

The synthesis of 15 possible metabolites of prolintane (1) (Katovit) which is used in the treatment of blood pressure disregualtions is described. Furthermore, the preparation of the enantiomers of 1 is reported, starting with R-(+)- and S-(-)-phenylalaninol respectively.