139928-78-2Relevant academic research and scientific papers
Synthesis of thioamides from thiocarboxylic acids using phosphonium-type condensing reagents
Suzuki, Ayaka,Takagi, Kazunori,Sato, Kazuki,Wada, Takeshi
, (2021)
The synthesis of thioamides via the condensation reaction of thiocarboxylic acids with amines is described. Using 3-cyano-1,2,4-triazole as a favorable nucleophilic catalyst and 3-cyano-1,2,4-triazol-1-yl-tris(pyrrolidine-1-yl)phosphonium hexafluorophosphate (PyCTP) as a new phosphonium-type condensing reagent, thioamides are obtained selectively over amides, which can be attributed to the hardness of the phosphorus center of the condensing reagent.
Chemo-enzymatic synthesis of Fmoc-peptide fragments
Chen,Hsiao,Chang,Wang
, p. 391 - 398 (2007/10/02)
Optically pure Fmoc-peptide fragments have been prepared via dicyclohexylcarbodiimide coupling of N-protected amino acids with amino cid esters, followed by enzyme-catalyzed ester hydrolysis by alcalase with a high concentration of organic solvent in a hi
